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A cell’s first steps: Building a model to explain how cells grow

ScienceDaily (May 18, 2012) ? A collaboration between Lehigh University physicists and University of Miami biologists addresses an important fundamental question in basic cell biology: How do living cells figure out when and where to grow?

The study, “Oscillatory Dynamics of Cdc42 GTPase In The Control of Polarized Growth,” appears May 18 in the journal Science Express.

Assistant Professor Dimitrios Vavylonis and graduate student Tyler Drake joined a University of Miami research team led by Associate Professor Fulvia Verde to learn that protein Cdc42 begins the ballet of proteins that change cell polarity, by oscillating throughout the cellular membrane of new cells. By changing polarity, Cdc42 regulates shape, structure and function in yeast cells. This oscillatory mechanism may be a general strategy among all self-organizing biological systems, not just simple yeast.

Researchers used fluorescent markers to tag each of the many proteins involved, observing the protein oscillate, switching sides about every five minutes. The fluctuations provide an adaptable mechanism for cells to control their size and structure in the fast-changing environment within.

The findings demonstrate just part of the complex process of cell growth and differentiation, but mark how advanced the science of biophysics has become. Only recently has the clear imaging and monitoring of protein activity become possible at the minute sizes and shortened time scales of individual cell maturation.

Vavylonis’s research has for years explored the way the cellular cytoskeleton organizes and functions. In collaboration with biologists and computer scientists, his team uses physics to study, analyze, and model the physical properties of these adaptive biological materials.

The study was funded by the National Science Foundation, the National Institutes of Health, and by individual university groups including a Lehigh Class of 1968 Junior Faculty Fellowship and a Sigma Xi grant to Drake.

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The above story is reprinted from materials provided by Lehigh University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. Das, T. Drake, D. J. Wiley, P. Buchwald, D. Vavylonis, F. Verde. Oscillatory Dynamics of Cdc42 GTPase in the Control of Polarized Growth. Science, 2012; DOI: 10.1126/science.1218377

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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State Bank Of India Car Loan ? Make Your Dream Car True ? Article …


State bank of India (SBI) is one of the most prominent banks in the country. The bank has years of experience in banking and financing sectors in India. The bank has been accredited as the most reputed and largest bank in India owing to its consistent and quality banking to the people of the nation. Moreover, being the government owned bank, people have trust on SBI?s loan products and insurance related services. The article features on car loan product of the bank.

Car/auto loan is one of the most remarkable products of SBI. The bank is reputed for offering quality and affordable auto loans at attractive rate of interest with easy repayment options. To ensure utmost customer?s satisfaction, the bank offers unlimited auto loan based on availability of 2.5 times loan amount on the annual income of the loan applicant. You are advised to add up additional incomes from your spouse/children/parents to accentuate car loan eligibility of SBI.

The repayment duration of SBI car loan borrowed varies according to both salaried and self-employed (84 months and 60 months respectively). Prepayment charge is also applicable as per the subjective conditions of the bank in this regard. Verification charge of your documents submitted to the bank accompanies processing charge of 0.50% as per the subjective conditions of the bank in respect with your housing loan.

The eligibility criteria of SBI for vehicle finance matter most for both salaried and self-employed applicants. It is therefore essential for both applicants to consider such criteria of the bank prior to applying for car loan. In a nut cell, eligibility criteria including age, current income, job experience and resident proof are demanded by state bank of India.

Adding further, State Bank Of India car loan involves submission of essential documents for both salaried and self-employed. As per the documents, both applicants need to submit financial documents, proof of age, identity proof, resident proof and other documents respectively as per the guidelines of SBI.

You should bear the facts in mind that improper information and other details pertaining to cancellation of your SBI?s auto finance application should be avoided. Most vehicle finance applicants wittingly try to pull the wool over bank?s eyes by supplying wrong and erroneous information. Avoidance of such acts will not only make you an eligible car loan applicant but it will also make you an apple of eye to the bank. Thus, it will help you avail other loans of SBI in future.

SBI car loan can give you sufficient loan amount so that you can finance your new car. However, there are certain terms to follow when it comes to applying for car loan from the bank. From following eligibility criteria to document procedures, both salaried and self-employed applicants need to be cautious and follow them properly.

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Leadership Is A Talent That Is Learnable And Which Can Bring …

The greatest benefit of becoming an excellent leader is that folk do things for you because they like to do things for you. Ex US President Dwight D. Eisenhower summed up this benefit sharply when he said: ?Leadership is the art of getting someone else to do something that you desire done because he wants to do it.?

There is a commonly quoted misconception that leaders are born and can never be made. Whist it?s correct that many leaders are people who?ve exceptional personality, self confidence and directional sense, it is also right that all of these are learned skills. Such abilities, when they appear to be totally natural are the result of the environment in which the perpetrator of the abilities has been brought up and the way that the individual has reacted to that environment. The critical point here is that the individual learned the abilities, they?re not the results of genetic structure.

A good way to learn to be an exceptional leader is to model yourself on the behaviour, principles and thinking of an exceptional leader. But you can learn the same abilities by studying books and going on good leadership coaching courses. Whichever method of learning you use you will turn into a good leader due to the way that you learn and implement the abilities you?re taught. Click here to learn more about my Dynamic Leadership Workshop.

Being a good leader requires that you develop the self-discipline to behave in a consistent way both with yourself and with those around you. One point that causes potential leaders to lose credibility with co-workers and team members is a dearth of consistency in their behavior.

If you want to be an outstanding leader you have got to have a deep-seated want to be an excellent leader for good reasons. There need to be clear benefits for you in being a leader. Therefore before you concentrate on becoming a leader think about what being a leader will do for you.

Imagine a precision instrument that records the actions, words and feelings of the best performers. Then download that data to a powerful decoder that analyses and codes the behaviour. Transfer the code to your personal control panel so that you can reproduce excellence at will. This is how NLP Techniques work. NLP Practitioner David Ferrers will show you how to build your own control panel during Business Coaching, or at one of his NLP Training workshops or during his Sales Success with NLP Training in India.

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Growing like gangbusters, Turkey says Western economies need ‘serious reforms’

Turkey’s Deputy Prime Minister Ali Babacan warned Friday that the US and Europe were not doing enough to resolve the core causes of the global economic slowdown.

The global economy remains deep in crisis and Europe and the United States are doing little to resolve its core causes, Deputy Turkish Prime Minister Ali Babacan warned Friday.

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Mr. Babacan, a former foreign minister and Turkey?s point-man for economic policy, said neither the US nor the eurozone countries have yet to deal with the underlying causes of the global economic slowdown: a weak financial sector, weak corporate balance sheets, risky public financial positions.?

Speaking at the Fletcher School of Law and Diplomacy at Tufts University, Babacan warned that this year will be a year of reckoning for the European Union, and he pointed to the recent collapse of the Dutch government over the budget austerity measures as a harbinger for Europe?s coming fiscal battles.?

?2012 will be test year for European countries,? he said. ?2013 will be test year for American economy. After the elections [the new administration] will find very difficult decisions on the table right away. There has to be serious fiscal adjustment and a medium term plan to deal with the deficit. So far, there is no credible plan to deal with deficit.?

Babacan said developed countries need to undertake serious structural changes including reforming social security and labor markets: ?It is absolutely necessary for serious reforms, especially in many European countries, absolutely necessary and urgent.?

Babacan is a founding member of Prime Minister Recep Tayyip Erdogan?s Justice and Development Party and considered a leading member of the ?Neo-Ottomanism? movement, moving Turkey?s foreign policy away from a predominantly Western focus to integration and activism in its immediate neighborhood ??the territories of the former Ottoman Empire.

Babacan contrasted the Western economic turmoil, with Turkey?s booming economy which he said grew at 9.2 percent growth rate in 2010, and 8.5 percent in 2011.

?We entered this crisis with a strong banking system and strong public financial structure. During the crisis when many countries were asking for fiscal stimulus programs.? We followed a very different route. We did just the opposite. We announced fiscal consolidation program. And we overperformed,? he said.

He said Turkey?s economy was far more open than many European countries, which had made Turkish companies more dynamic and more competitive in global markets. And he argued that Turkish growth was more sustainable because he said it didn?t come on the back of government spending, but rather private sector growth.

In the coming years, he said, ?We will have lower growth ??though better than everywhere else in Europe ??but slower than before. Growth is high, but it?s also sustainable growth.?

?Tight fiscal policies will continue, in good days or in bad days,? he said, ?but we don?t believe in economic growth through public spending.?

Islam, democracy, and capitalism

Turkey has shown how Islam and democracy and capitalism can cooexist peacefully, Babacan said.?

?When people observe a functioning example, people are more encouraged to ask for more in their own countries,? he said. ?We have been talking with leaders: Change is coming, you can no longer have a closed regime with an open society ??satellites, social media, the Internet ??you have this kind, this kind of society moving forward and you are running this closed regime, this is not sustainable, this cannot continue.?

?We have advised these leaders to lead this change, or you will be pushed by change anyway,? he said. ?

Babacan addressed several of the long-running disputes in the region, such as the Israeli-Palestinian impasse, the status of the split island of Cyprus, and the violence in neighboring Syria. He said Turkey was strongly supportive of the six-point peace plan pushed by former United Nations Secretary General Kofi Annan, but he said Turkey was strongly against any sort of military intervention or sending weapons to the embattled Syrian opposition forces.

He also said the Syrian opposition is coalescing into a viable alternative to the regime of Syrian President Bashar al-Assad.

?We need to see visible, verifiable, and indisputable change in the country,? he said. ?The primary responsibility to end the violence will rest with the Syrian regime.?

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Buddy Roemer, the Anti-Spoiler (Atlantic Politics Channel)

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What’s causing mass pelican and dolphin deaths in Peru?

Delays in the autopsies of thousands of dead pelicans and dolphins in Peru are causing difficulties for officials as they attempt to determine causes of death in these die-offs.

The carcasses of dead pelicans still litter the beaches of northern Peru, even as the last of nearly 900 dolphins are cleared away.

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The mass die-offs have Peruvian scientists searching for a cause and environmentalists raising questions about the government’s ability to protect the Pacific nation’s marine life, among the world’s most abundant thanks to the Humboldt current that hugs most of its 1,500-mile (2,400-kilometer) coast.

After weeks of study, investigators say they think they know why at least 4,450 pelicans have died: Hotter than usual ocean temperatures have driven a type of anchovy deeper into the sea, beyond the reach of many young pelicans.

But Peruvian scientists studying the deaths of dolphins and porpoises from early February to mid-April say it remains a mystery, due in part to the government’s slowness in investigating the phenomenon.

Authorities were so late in gathering tissues from the mammals that crucial clues were likely lost, said the scientist heading the dolphin death probe, Armando Hung, head of the molecular biology lab at Cayetano Heredia University.

At the same time, local officials have been so slow in removing carcasses that the Health Ministry urged the public last weekend to stay away from beaches from Lima, the coastal capital, northward, though it did not identify any specific health issue.

Up and down the coast, disoriented pelicans have been seen standing on beaches where they don’t normally alight. Some have even been seen walking along coastal roadways.

Beginning at the end of January, daily catches of about 5 tons of anchovetas a day by fishermen in the northern region of Lambayeque dwindled after they began finding the small fish dead on the beach, said Fernando Nique, president of the Puerto Eten fishermen’s association.

“After that, we haven’t seen any more anchoveta,” he said.

Patricia Majluf, a biologist and former deputy fisheries minister, said that tongues of warm water reach into coastal zones, driving anchovetas deeper underwater where many birds can’t reach them.

“For a coast as dynamic as ours, it’s not rare that this occurs,” said Majluf. “It looks ugly because this has occurred at the same time and place (as the dolphin deaths).”

A biologist at the National University of Trujillo, Carlos Bocanegra, said his analysis of 10 dying pelicans last week supports that theory. Their digestive tracts were either empty or had the remains of fish pelicans don’t normally eat.

Scientists say the dead pelicans are generally young, 3-4 years old, an age in which they do not dive as deep as their elders.

Ocean temperatures in the region, said Bocanegra, are currently 6 degrees Celsius (10 degrees Fahrenheit) above normal for this time of year, Peru’s autumn.

A similar pelican die-off happened in 1982-1983 and again in 1997-1998 when the El Nino meteorological phenomena warmed the ocean, Bocanegra said.

“We saw mass deaths along Peru’s entire coast, also associated with high sea temperatures. Pelicans, cormorants, Peruvian boobies and guanay cormorants died,” he said.

The dolphin die-off, by contrast, remains a mystery.

Hung told The Associated Press that lab tests have so far ruled out a number of bacterial infections as the cause of the dolphin deaths, though other tests remain.

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Friday Afternoon Jam: Bob Schneider – Honeypot (Little green footballs)

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Women ponder how they became a campaign issue (The Arizona Republic)

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Friday Afternoon Jam: Bob Schneider – Honeypot (Little green footballs)

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Louis CK Secretly Releases Another Online-Only Special

Screen Shot 2012-05-11 at 2.24.07 PMComedian Louis CK has just released a new comedy special, WORD: Live At Carnegie Hall as another download/streaming offering. The special costs $5 and follows on the heels of his previous special, Live At The Beacon Theatre. CK did no preliminary press for the release and this special contains content that fans might recognize from other live shows as well as his TV program, Louie.

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